Because Zoloft leaves your body so quickly, stopping it too abruptly can cause discontinuation syndrome to develop. Among the symptoms that may be experienced are nausea, tremor, dizziness, muscle pains, weakness, insomnia, and anxiety. I'll get right to the point.zoloft withdrawal is not fun and can be a pain in the butt. A supplement that will help you a lot is a good antioxidant supplement. Think of it this way antioxidants will save those neurotransmitters that are firing normally. Valerian root is also another one that is great for sleep. One possible way to get relief is to take a single 20 milligram (mg) dose of Prozac. Your symptoms will likely go away within a few hours. And because of Prozac's long half-life, you won't have withdrawal symptoms after taking that one capsule. Ask your doctor about this option if your symptoms are bothersome. Zoloft withdrawal, some odd side effects. Jessica I recently began experiencing some really crazy symptoms and this was within the same week that I went off Zoloft, kind of weaning myself off. Continued Hardest-to-Stop Antidepressants. All depression drugs can potentially lead to discontinuation symptoms, but some are much more likely to do so than others. Confusion is a common withdrawal symptom along with memory issues. It is especially common if you stopped taking Zoloft “cold turkey.” It is especially common if you stopped taking Zoloft “cold turkey.” To minimize the risk of antidepressant withdrawal, talk with your doctor before you stop taking an antidepressant. Your doctor may recommend that you gradually reduce the dose of your antidepressant for several weeks or more to allow your body to adapt to the absence of the medication. Zoloft Withdrawal and Tapering Help. Because SSRI's influence numerous systems of the body and brain, stopping Zoloft abruptly can cause a discontinuation syndrome known as withdrawal. Because SSRI's influence numerous systems of the body and brain, stopping Zoloft abruptly can cause a discontinuation syndrome known as withdrawal. Two months AFTER being off Zoloft I continued to have withdrawal symptoms My last Zoloft dose, and I tapered down slowly, was 8-31-06. I then had to taper down and go off Xanax (last Xanax dose was yesterday, 12-14-06).